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Spatial comparison of CT-based surrogates of lung ventilation with hyperpolarized Helium-3 and Xenon-129 gas MRI in patients undergoing radiation therapy

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标题: Spatial comparison of CT-based surrogates of lung ventilation with hyperpolarized Helium-3 and Xenon-129 gas MRI in patients undergoing radiation therapy
资源摘要: Publication date: Available online 10 May 2018
Source:International Journal of Radiation Oncology*Biology*Physics

Author(s): B.A. Tahir, P.J.C. Hughes, S.D. Robinson, H. Marshall, N.J. Stewart, G. Norquay, A. Biancardi, H.-F. Chan, G.J. Collier, K.A. Hart, J.A. Swinscoe, M.Q. Hatton, J.M. Wild, R.H. Ireland

Purpose To develop and apply an image acquisition and analysis strategy for spatial comparison of CT-ventilation images with hyperpolarized gas MRI. Methods 11 lung cancer patients underwent 129Xe and 3He ventilation MRI and co-registered 1H anatomical MRI. Expiratory and inspiratory breath-hold CTs were used for deformable image registration and calculation of three CT-ventilation metrics: Hounsfield unit (CTHU), Jacobian (CTJac) and specific gas volume change (CTSGV). Inspiration CT and hyperpolarized gas ventilation MRI were registered via same-breath anatomical 1H-MRI. Voxel-wise Spearman correlation coefficients were calculated between each CT-ventilation image and its corresponding 3He/129Xe-MRI, and for the mean values in regions of interest (ROIs) ranging from fine to coarse in-plane dimensions of 5x5, 10x10, 15x15 and 20x20, located within the lungs as defined by the same-breath 1H-MRI lung mask. Correlation of 3He and 129Xe-MRI was also assessed. Results Spatial correlation of CT-ventilation against 3He/129Xe-MRI increased with ROI size. For example, for CTHU, mean±SD Spearman coefficients were 0.37±0.19/0.33±0.17 at the voxel-level and 0.52±0.20/0.51±0.18 for 20x20 ROIs, respectively. Correlations were stronger for CTHU than for CTJac or CTSGV. Correlation of 3He with 129Xe-MRI was consistently higher than either gas against CT-ventilation maps over all ROIs (p<0.05). No significant differences were observed between CT-ventilation vs 3He-MRI and CT-ventilation vs 129Xe-MRI. Conclusion Comparison of ventilation-related measures from CT and registered hyperpolarized gas MRI is feasible at a voxel level using a dedicated acquisition and analysis protocol. Moderate correlation between CT-ventilation and MRI exists at a regional level. Correlation between MRI and CT is significantly less than between 3He and 129Xe-MRI, suggesting that CT-ventilation surrogate measures may not be measuring lung ventilation alone.

Teaser

This paper describes: an imaging protocol for acquiring pulmonary CT, 1H, 3He and 129Xe-MRI with similar breath-holds and posture to facilitate accurate spatial comparison of CT-ventilation and hyperpolarized gas ventilation maps via deformable image registration, a validation of CT-ventilation, generated from multi-inflation breath-hold CT, against hyperpolarized gas MRI, a comparison of CT-ventilation against two commonly-used hyperpolarized noble gases (3He and 129Xe) for ventilation imaging, a voxel-wise and ROI-based comparison of CT-ventilation and hyperpolarized gas MRI.



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资源来源机构: Elsevier
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