科研成果

著作

2. Xin Zhou. Chapter<<Hyperpolarized Xenon Brain MRI >>in book<<Advances in Brain Imaging >>, InTech, USA. (2012).

1. Xin Zhou. Chapter<<Hyperpolarized Noble Gases as Contrast Agents >>in book<<In vivo NMR Imaging: Methods and Protocols>>, Humana Press, USA. (2011).

 

发表文章(*通讯作者)

63. Qiaoli Peng, Yaping Yuan, Huaibin Zhang, Shaowei Bo, Yu Li, Shizhen Chen, Zhigang Yang, Xin Zhou, Zhongxing Jiang*. 19F CEST Imaging Probes for Metal Ion Detection. Organic & Biomolecular Chemistry, Vol 15(30), 6441-6446. (2017). DOI:10.1039/C7OB01068K. pdf

62. Xin Liu, Yaping Yuan, Shaowei Bo, Zhigang Yang, Xin Zhou, Shizhen Chen, Zhongxing Jiang*. Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with 19F Magnetic Resonance. European Journal of Organic Chemistry, Vol 2017(30), 4461-4468. (2017). DOI:10.1002/ejoc.201700566. pdf

61. Yuqi Yang#, Shizhen Chen#, Lianhua Liu, Sha Li, Qingbin Zeng, Xiuchao Zhao, Haidong Li, Zhiying Zhang, Louis-S. Bouchard, Maili Liu, Xin Zhou*. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation. ACS Applied Materials & Interfaces. (2017)DOI: 10.1021/acsami.7b05463. pdf

60. Jianping Zhong, Huiting Zhang, Weiwei Ruan, Junshuai Xie, Haidong Li, He Deng, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Simultaneous Assessment of Both Lung Morphometry and Gas Exchange Function within a Single Breath-hold by Hyperpolarized 129Xe MRI. NMR in Biomedicine. (2017). DOI:10.1002/nbm.3730pdf 

59. Shengjun Yang, Yaping Yuan, Weiping Jiang, Lili Ren, He Deng, Louis-S. Bouchard, Xin Zhou*, Maili Liu*. Hyperpolarized 129Xe MRI Sensor for H2SChemistry - A European Journal. (2017).  DOI:10.1002/chem.201605768. pdf

58. Beatriz Pelaz, et. al., Xin Zhou and Wolfgang J. Parak*. Diverse Applications of Nanomedicine. ACS Nano, 11(3), 2313-2381. (2017). DOI:10.1021/acsnano.6b06040. pdf

57. Conggang Li*, Jiajing Zhao, Kai Cheng, Yuwei Ge, Qiong Wu, Yansheng Ye, Guohua Xu, Zeting Zhang, Wenwen Zheng, Xu Zhang, Xin Zhou, Gary Pielak, Maili Liu*. Magnetic Resonance Spectroscopy As a Tool for Assessing Macromolecular Structure and Function in Living Cells.  Annual Review of Analytical Chemistry, Vol 10, 9.1-9.26. (2017). DOI:10.1146/annurev-anchem-061516-045237. pdf 

56. Qingbin Zeng#, Qianni Guo#, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S. Bouchard, Xin Zhou*.  Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized 129Xe Magnetofluorescent Biosensor. Analytical Chemistry, Vol 88(4), 2288-2295. (2017)DOI: 10.1021/acs.analchem.6b03742pdf

55. Weiwei Ruan, Jianping Zhong, Ke Wang, Guangyao Wu, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Detection of the Mild Emphysema by Quantification of Lung Respiratory Airways With Hyperpolarized Xenon Diffusion MRI. Journal of Magnetic Resonance Imaging, Vol 45(3), 879-888. (2017). DOI:10.1002/jmri.25408pdf 

54. He Deng, Wankai Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Mammogram Enhancement Using Intuitionistic Fuzzy Sets. IEEE Transactions on Biomedical Engineering,Vol 64(8), 1803-1814. (2017). DOI:10.1109/TBME.2016.2624306pdf

53. Weiwei Ruan, Jianping Zhong, Yu Guan, Yi Xia, Xiuchao Zhao, Yeqing Han, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou*.  Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized 129Xe Diffusion Kurtosis Imaging in Rat Models. Magnetic Resonance in Medicine. (2016)DOI:10.1002/mrm.26566. pdf

52. He Deng, Wankai Deng, Xianping Sun, ChaohuiYe, Xin Zhou*. Adaptive Intuitionistic Fuzzy Enhancement of Brain Tumor MR ImagesScientific Reports, Vol 6, 35760.(2016). DOI:10.1038/srep35760. pdf

51. Iris Yuwen Zhou, Taylar L. Fuss, Takahiro Igarashi, Weiping JiangXin Zhou, Leo L. Cheng, Phillip Zhe Sun*. Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy. Analytical Chemistry, Vol 88(21), 10379-10383. (2016). DOI: 10.1021/acs.analchem.6b03137. pdf   

50. Yu Li, Guiquan Xia, Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, Wei Wang, ZhongYin Zhang, Xin Zhou, ZhongXing Jiang*. Design, Synthesis and Evaluation of Novel 19F Magnetic Resonance Sensitive Protein Tyrosine Phosphatase Inhibitors. Medicinal Chemistry Communication, Vol 7(8), 1672-1680. (2016). DOI: 10.1039/C6MD00277C. pdf

49. Zhiying Zhang, Yu Guan, Haidong Li, Xiuchao Zhao, Yeqing Han, Yi Xia, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou*. Quantitative Comparison of Lung Physiological Parameters in Single and Multiple Breathhold with Hyperpolarized Xenon Magnetic Resonance. Biomedical Physics & Engineering Express, Vol 2(5). (2016).  DOI:10.1088/2057-1976/2/5/055013. pdf

48. He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Entropy-based Window Selection for Detecting Dim and Small Infrared TargetsPattern Recognition, Vol 61(2017), 66-77(2016). DOI:10.16/j.patcog.2016.07.036pdf 

47Haidong Li, Zhiying Zhang, Xiuchao Zhao, Xianping Sun, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Radiation-Induced Lung Injury with Hyperpolarized Xenon Magnetic Resonance. Magnetic Resonance in Medicine, Vol 76(2), 408-416. (2016). DOI:10.1002/mrm.25894 pdf

46. Weiping Jiang, Iris Yuwen Zhou, Lingyi Wen, Xin Zhou*, Phillip Zhe Sun*. A Theoretical Analysis of Chemical Exchange Saturation Transfer Echo Planar Imaging (CEST-EPI) Steady State Solution and the CEST Sensitivity Efficiency-based Optimization ApproachContract Media & Molecular Imaging, Vol 11(5), 415-423.  (2016). DOI: 10.1002/cmmi.1699pdf

45. Jianping Zhong, Weiwei Ruan, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Fast Determination of Flip Angle and T1 in Hyperpolarized Gas MRI During a Single Breath-Hold. Scientific Reports, Vol 6, 25854. (2016). DOI: 10.1038/srep25854. pdf

44. He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Image Enhancement Based on Intuitionistic Fuzzy Sets Theory. IET Image Processing, Vol 10(10), 701-709.(2016). DOI:10.1049/iet-ipr.2016.0035. pdf

43. Shengjun Yang, Weiping Jiang, Lili Ren, Yaping Yuan, Bin Zhang, Qing Luo, Qianni Guo, Louis-S. Bouchard, Maili Liu, Xin Zhou*. Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction. Analytical Chemistry, Vol 88(11), 5835-5840. (2016). DOI:10.1021/acs.analchem.6b00403. pdf

42. He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Small Infrared Target Detection Based on Weighted Local Difference MeasureIEEE Transactions on Geoscience and Remote Sensing, Vol 54(7), 4204-4214. (2016). DOI: 10.1019/TGRS.2016.2538295. pdf

41. Qiuyan Shi, Yu Li, Shaowei Bo, Xiaofei Li, Peng Zhao, Qi Liu, Zhigang Yang, Hengjiang Cong, Hexiang Deng, Mingnan Chen, Shizhen Chen, Xin Zhou, Hong Ding, Zhongxing Jiang*. Discovery of a 19F MRI Sensitive Salinomycin Derivative with High Cytotoxicity Towards Cancer CellsChemical Communications, Vol 52, 5136-5139. (2016). DOI: 10.1039/C6CC01508E. pdf

40. Lili Ren#, Shizhen Chen#, Haidong Li, Zhiying Zhang, Jianping Zhong, Maili Liu, Xin Zhou*. MRI-Guided Liposomes for Targeted Tandem Chemotherapy and Therapeutic Response PredictionActa BiomaterialiaVol 35, 260-268. (2016). DOI: 10.1016/j.actbio.2016.02.011. pdf

39. Qianni Guo, Qingbin Zeng, Weiping Jiang, Xiaoxiao Zhang, Qing Luo, Xu Zhang, Louis-S. Bouchard, Maili Liu, Xin Zhou*. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp ProbeChemistry - A European Journal, Vol 22, 3967-3970(2016). DOI: 10.1002/chem.201600193. pdf

38. Haidong Li#, Zhiying Zhang#, Jianping Zhong, Weiwei Ruan, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Oxygen-Dependent Hyperpolarized 129Xe Brain MR. NMR in Biomedicine, Vol 29(3), 220-225. (2016). DOI: 10.1002/nbm.3465. pdf

37. Bo Li, Xudong Wang, Yali Guo, Anam Iqbal, Yaping Dong, Wu Li, Weisheng Liu, Wenwu Qin*, Shizhen Chen, Xin Zhou, Yunhuang Yang*. One-Pot Synthesis Polyamines Improved Magnetism and Fluorescence Fe3O4-Carbon Dots Hybrid NPs for Dual Modal Imaging. Dalton Transactions, Vol 45, 5484-5491. (2016). DOI:10.1039/C5DT04488J. pdf 

36. He Deng, Jianping Zhong, Weiwei Ruan, Xian Chen, Xianping Sun, Chaohui Ye, Maili Liu, Xin Zhou*. Constant-Variable Flip Angles for Hyperpolarized Media MRI. Journal of Magnetic Resonance, Vol 263(2), 92-100. (2016). DOI:10.1016/j.jmr.2015.12.022pdf

35. Yuhui Chai, Guoqiang Bi, Liping Wang, Fuqiang Xu, Ruiqi Wu, Xin Zhou, Bensheng Qiu, Hao Lei, Yaoyu Zhang, Jiahong Gao*Direct Detection of Optogenetically Evoked Oscillatory Neuronal Electrical Activity in Rats Using SLOE Sequence. NeuroImage, Vol 125, 533–543. (2016). DOI:10.1016/j.neuroimage.2015.10.058. pdf

34Xia Jiang, Jingwei Sheng, Huanjie Li, Yuhui Chai, Xin Zhou, Bing Wu, Xiaodong Guo, Jiahong Gao*. Detection of Subnanotesla Oscillatory Magnetic Fields Using MRI. Magnetic Resonance in Medicine, Vol 75(2), 519-526. (2016). DOI:10.1002/mrm.25553 pdf

33. He Deng, Xianping Sun, Maili Liu, Chaohui Ye, Xin Zhou*. Infrared Small Target Detection Using Multiscale-Gray-Difference Weighted Image Entropy. IEEE Transactions on Aerospace and Electronic Systems, Vol 52(1), 60-72. (2015). DOI:10.1109/TAES.2015.140878. pdf.

32Xiuchao Zhao, Xianping Sun, Maohua Zhu, Xiaofei Wang, Chaohui Ye, Xin Zhou*. Atomic Filter Based on Stimulated Raman Transition at the Rubidium D1 Line. Optics Express, Vol 23(14), 17988-17994. (2015). DOI:10.1364/OE.23.017988 pdf

31. Weiwei Ruan, Jianping Zhong, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI. Chinese Journal of Magnetic Resonance, Vol 32(2), 261-272. (2015). DOI:10.11938/cjmr20150209 pdf

30Shaowei Bo, Cong Song, Yu Li, Weijiang Yu, Shizhen Chen, Xin Zhou, Zhigang Yang, Xing Zheng*, Zhongxing Jiang*Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly. The Journal of Organic Chemistry,  Vol 80(12), 6360-6366.  (2015).  DOI:10.1021/acs.joc.5b00810 . pdf

29. Lili Ren, Shizhen Chen, Haidong Li, Zhiying Zhang, Chaohui Ye, Maili Liu, Xin Zhou*. MRI-Visible Liposome Nanovehicles for Potential Tumor-Targeted Delivery of Multimodal Therapies. Nanoscale, Vol 7, 12843-12850. (2015). DOI:10.1039/C5NR02144H.  pdf

28. Weijiang Yu, Yuqi Yang, Shaowei Bo, Yu Li, Shizhen Chen, Zhigang Yang, Xing Zheng, Zhongxing Jiang*, Xin ZhouDesign and Synthesis of Fluorinated Dendrimers for Sensitive 19F MRI. The Journal of Organic Chemistry, Vol 80(9), 4443-4449. (2015). DOI:10.1021/acs.joc.5b00294 pdf

27Xiaolei Zhu, Shizhen Chen, Qing Luo, Chaohui Ye, Maili Liu, Xin Zhou*. Body Temperature Sensitive Micelles for MRI Enhancement. Chemical CommunicationsVol 51(44), 9085-9088. (2015).  DOI:10.1039/C5CC02587G.  pdf

26Ling Zhu, Guangyao Wu*, Xin Zhou, Jielan Li, Zhi Wen, Fuchun Lin*. Altered Spontaneous Brain Activity in Patients with Acute Spinal Cord Injury Revealed by Resting-State Functional MRI. PLoS ONE, Vol 10(3), e0118816. (2015). DOI:10.1371/journal.pone.0118816 pdf

25Qi Wang, Shizhen Chen, Qing Luo, Maili Liu, Xin Zhou*. A Europium-Lipoprotein Nanocomposite for High-Sensitive MR-Fluorescence Multimodal Imaging. RSC Advances, Vol 5(3), 1808-1811. (2015). DOI:10.1039/c4ra12201a pdf

24. Zheng Tan, Xianping Sun*, Jun Luo, Yong Cheng, Xiuchao Zhao, Xin Zhou, Jin Wang, Mingsheng Zhan*. Ultranarrow Bandwidth Tunable Atomic Filter via Quantum Interference-Induced Polarization Rotation in Rb Vapor. Chinese Optics Letters, Vol 12(12), 121404. (2014). DOI:10.3788/COL201412.121404. pdf

23. Ji Zhang, Weiping Jiang, Qing Luo, Xiaoxiao Zhang, Qianni Guo, Maili Liu, Xin Zhou*. Rational Design of Hyperpolarized Xenon NMR Molecular Sensor for Selective and Sensitive Determination of Zinc Ions. TalantaVol 122, 101-105. (2014). DOI:10.1016/j.talanta.2014.01.023.  pdf

22. Qianni Guo, Qingbin Zeng, Xiaoxiao Zhang, Xin Zhou*. Highly Sensitive Detection of Mercury (II) in Aqueous Media by Tetraphenylporphyrin with a Metal Ion Receptor. Supramolecular Chemistry, Vol 26(10-12), 836-842. (2014).  DOI:10.1080/10610278.2014.882512.  pdf

21. Shizhen Chen, Yuqi Yang, Haidong Li, Xin Zhou*, Maili Liu. pH-Triggered Au-Fluorescent Mesoporous Silica Nanoparticles for 19F MR/Fluorescent Multimodal Cancer Cellular ImagingChemical Communications, Vol 50, 283-285. (2014).  DOI:10.1039/C3CC47324D.  pdf

20. Guobin Liu, Xiaofeng Li, Xianping Sun, Jiwen Feng, Chaohui Ye, Xin Zhou*. Ultralow Field NMR Spectrometer with an Atomic Magnetometer Near Room TemperatureJournal of Magnetic Resonance, Vol 237, 158-163. (2013).  DOI:10.1016/j.jmr.2013.10.008.  pdf

19. Yuanyuan Du, Wenxian Lan, Zhusheng Ji, Xu Zhang, Bin Jiang, Xin Zhou, Conggang Li, Maili Liu*. NMR Spectroscopic Approach Reveals Metabolic Diversity of Human Blood Plasma Associated with Protein-Drug Interaction. Analytical Chemistry, Vol 85(18), 8601-8608. (2013).  DOI:10.1021/ac401738z.  pdf

18. Zheng Tan, Xiuchao Zhao, Yong Cheng, Xianping Sun*, Jun Luo, Xin Zhou, Jin Wang, Mingsheng Zhan*. Doppler-Free Spectroscopy of Rubidium Atoms Driven by a Control Laser. Frontier of Physics, Vol 7(3), 311-314. (2012). DOI:10.1007/s11467-011-0192-1. pdf

17. Mary Mazzanti, Ronn Walvick, Xin Zhou*, Yanping Sun, Niral Shah, Joey Mansour, Jessica Gereige, Mitchell Albert*. Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings. PLoS ONE, Vol 6(7), e21607. (2011).  DOI:10.1371/journal.pone.0021607 pdf

16. Xin Zhou*, Yanping Sun, Mary Mazzanti, Nils Henninger, Joey Mansour, Marc Fisher, Mitchell Albert. MRI of Stroke Using Hyperpolarized 129Xe. NMR in Biomedicine, Vol 24(2), 170-175. (2011).  DOI:10.1002/nbm.1568.  pdf. Highlighted by UMass Medical News.

15. Xin Zhou, Dominic Graziani, Alexander Pines*. Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction. The Proceedings of the National Academy of Sciences, USA, Vol 106(40), 16903-16906. (2009).  DOI:10 .1073/pnas.0909147106. pdfHighlighted by Science Daily, Future Medicine, DOTMed News,  New York Academy of Sciences, etc.

14. Xin Zhou*, Xianping Sun, Jun Luo, Mingsheng Zhan, Maili Liu. Quantitative Estimation of SPINOE Enhancement in Solid State. Journal of Magnetic  Resonance, Vol 196, 200-203. (2009).  DOI:10.1016/j.jmr. 2008.11.006.  pdf

13. Xin Zhou*, Mary Mazzanti, Jianbing James Chen, YangSheng Tzeng, Joey Mansour, Jessica Gereige, Arvind Venkatesh, Yanping Sun, Robert Mulkern, Mitchell lbert. Reinvestigating Hyperpolarized 129Xe Longitudinal Relaxation Time in the Rat Brain with Noise Considerations. NMR in Biomedicine, Vol 21(3), 217-225.  (2008).  DOI:10.1002/nbm.1184.  pdf

12. YangSheng Tzeng*, Joey Mansour, Zachary Handler, Jessica Gereige, Niral Shah, Xin Zhou, Mitchell Albert. Measurement of the Internal Diameter of Plastic Tubes from Projection MR Images Using a Model-based Least-squares Fit ApproachMedical Physics, Vol 33(6), 1643-1653. (2006). DOI: 10.1118/1.2194427. pdf

11. Xin Zhou*, Jun Luo, Xianping Sun, Xizhi Zeng, Shangwu Ding, Maili Liu, Mingsheng Zhan. Enhancement of Solidstate Proton NMR via SPINOE with Laser-Polarized Xenon. Physical Review B, Vol 70(5), 052405. (2004).  DOI:10.1103/PhysRevB.70.052405.  pdf

10. Xin Zhou*, Jun Luo, Xianping Sun, Xizhi Zeng, Mingsheng Zhan, Shangwu Ding, Maili Liu. Experiment and Dynamic Simulations of Radiation Damping of Laserpolarized Liquid 129Xe at Low Magnetic Field in a Flow System. Applied Magnetic Resonance, Vol 26(3), 327-337. (2004).  DOI:10.1007/BF03166805.  pdf

9. Xin Zhou*, Xianping Sun, Jun Luo, Xizhi Zeng, Maili Liu, Mingsheng Zhan. Production of Hyerpolarized 129Xe Gas without Nitrogen by Optical Pumping at 133Cs D2 Line in Flow System. Chinese Physics Letters, Vol 21(8), 1501-1503. (2004).  DOI:10.1088/0256-307X/21/8/024.  pdf

8. 肖洒,吕植成,孙献平,叶朝辉,周欣*. CS-MRI中评价随机欠采样矩阵的新方法波谱学杂志Vol 32(4)584-595. (2015).  pdf

7. 李海东,张智颖,韩叶清,孙献平,周欣*超极化气体肺部磁共振成像波谱学杂志Vol 31(3)307-448. (2014).  pdf

6. 曾庆斌,郭茜旎,罗晴,吴光耀,周欣*. 锰对比剂在MRI中的应用磁共振成像Vol 5(4)315-320. (2014).  DOI:10.3969/j.issn.1674-8034.2014.04.016. pdf

5. 张继,罗晴,郭茜旎,陈世桢,周欣*超极化129Xe磁共振分子影像学. 波谱学杂志, Vol 30(2), 279-292. (2013).  pdf

4. 张智颖,李海东,李昭,孙献平,吴光耀,周欣*肺部超极化气体MR成像. 中国医学影像技术, Vol 29(5), 813-817.( 2013).  pdf

3. 蒋卫平,王琦, 周欣*. 磁共振波谱与成像技术. 物理(特邀综述), Vol 42(12), 826-837. (2013).  DOI:10.7693/wl20131201.  pdf

2. 刘国宾,孙献平,顾思洪,冯继文,周欣*高灵敏度原子磁力计研究进展. 物理, Vol 41(12), 803-810. (2012).  pdf

1. 孙献平,韩叶清,罗晴,周欣*超极化129Xe磁共振波谱和成像及在生物医学中的应用物理, Vol 40(6), 379-388. (2011).(约稿).  pdf